Figure 7.

CD169 Plays a Crucial Role in Activating cDC1s to Elicit Effective CD8⁺ T Cell Response during FVC Infection

(A and B) CD80⁺-activated dendritic cells in CD11c^hi (A) and CD11c⁺CD8α⁺ (cDC1) (B) populations from splenocytes of FVC-infected B6.Fv2^s/s (n = 5) and B6.Fv2^s/sCD169^−/− (n = 5) (8 dpi, 2,500 SFFU s.c.).

(C) FVC-infected cells in the spleens of B6 (with and without CD8 T cell depletion), Batf3^−/−, and CD169^−/− mice (n = 4, 7 dpi, 2,500 SFFU r.o.).

p values derived from non-parametric Mann-Whitney test; mean values denoted by horizontal line; error bars denote SD. Scale bars as indicated. See also Figure S7 and Video S2.