Table 1.
Baseline characteristics of the study participants stratified into three groups according to Prevotella-to-Bacteroides (P/B) ratio
| 0-Prevotella1 (n = 8) | Low P/B group (n = 27) | High P/B group (n = 17) | P-value | |
|---|---|---|---|---|
| Age (year) | 47.9 ± 6.8 | 43.4 ± 8.7 | 41.8 ± 11.5 | 0.33 |
| Gender (% female/male) | 100/0 | 88.9/11.1 | 76.5/23.5 | 0.24 |
| Body weight (kg) | 82.6 ± 4.6a | 84.5 ± 11.4a | 95.1 ± 12.0b | 0.005 |
| Body mass index (kg/m2) | 30.7 ± 1.1a, b | 29.7 ± 2.2a | 31.9 ± 2.8b | 0.017 |
| Body fat (%) | 48.7 ± 3.9 | 44.9 ± 4.1 | 44.4 ± 5.02 | 0.069 |
| Fasting glucose (mmol/L) | 5.42 ± 0.46 | 5.55 ± 0.37 | 5.70 ± 0.55 | 0.33 |
| Fasting insulin (pmol/L) | 63.4 (47.0; 88.1) | 38.5 (23.7; 69.3)3 | 47.8 (28.8; 54.6) | 0.17 |
| Prevotella (relative abundance) | 0 (0; 0)a | 0.0003 (0.0002; 0.001)b | 0.155 (0.052; 0.278)c | <0.001 |
| Bacteroides (relative abundance) | 0.097 (0.032; 0.139)a | 0.071 (0.036; 0.111)a | 0.012 (0.007; 0.021)b | <0.001 |
| Prevotella-to-Bacteroides ratio | – | 0.004 (0.001; 0.012) | 11.67 (3.11; 36.03) |
Data are presented as mean ± standard deviation, median (interquartile range) or proportions (%) and differences between the three P/B groups were tested using one-way ANOVA with Bonferroni post-hoc tests (some variables transformed before analysis) or Pearson’s chi-squared test. Different alphabets within a row (a, b, c) indicate significant differences (P < 0.05)
P/B Prevotella-to-Bacteroides
10-Prevotella refers to the group of individuals with no detectable Prevotella spp. before intervention.
2n = 16 (missing data for one individual)
3n = 26 (missing data for one individual)