Table 3.
Change in body weight among the three Prevotella-to-Bacteriodes (P/B) groups stratified by median of self-reported dietary intake (n = 51)
| 0-Prevotella (n = 8) | Low P/B (n = 26) | High P/B (n = 17) | |||||
|---|---|---|---|---|---|---|---|
| Lower median | Higher median | Lower median | Higher median | Lower median | Higher median | ||
| Fat (E%)1 | (n = 3) | (n = 5) | (n = 11) | (n = 15) | (n = 7) | (n = 10) | |
| M1 | −6.3 (−9.8; −2.8) | −13.0 (−15.7; −10.3)2 | −6.4 (−8.2; −4.6) | −5.6 (−7.2; −4.1) | −12.2 (−14.4; −9.9) | −7.5 (−9.4; −5.6)2 | |
| M2 | −6.0 (−9.5; −2.4) | −13.0 (−15.5; −10.5)2 | −6.0 (−7.7; −4.3) | −5.9 (−7.5; −4.4) | −12.8 (−15.1; −10.6) | −8.1 (−10.0; −6.3)2 | |
| M3 | −3.0 (−6.2; 0.3) | −13.8 (−16.1; −11.6)2 | −4.9 (−6.5; −3.4) | −6.9 (−8.3; −5.5) | −11.6 (−13.7; −9.4) | −9.6 (−11.3; −7.8) | |
| Protein (E%)1 | (n = 4) | (n = 4) | (n = 11) | (n = 15) | (n = 12) | (n = 5) | |
| M1 | −11.1 (−14.1; −8.2) | −9.9 (−12.8; −6.9) | −6.5 (−8.3; −4.7) | −5.6 (−7.1; −4.1) | −7.6 (−9.3; −5.9) | −13.6 (−16.3; −11.0)2 | |
| M2 | −10.8 (−13.7; −8.0) | −8.9 (−11.8; −6.0) | −6.1 (−7.7; −4.5) | −5.9 (−7.4; −4.3) | −8.4 (−10.1; −6.8) | −14.8 (−17.6; −12.0)2 | |
| M3 | −10.4 (−13.1; −7.6) | −9.3 (−12.1; −6.4) | −6.1 (−7.8; −4.5) | −5.7 (−7.2; −4.2) | −8.6 (−10.3; −7.0) | −14.8 (−17.5; −12.1)2 | |
| Carbohydrate (E%)1 | (n = 6) | (n = 2) | (n = 12) | (n = 14) | (n = 8) | (n = 9) | |
| M1 | −9.2 (−11.5; −6.9) | −14.4 (−18.3; −10.4)2 | −5.2 (−6.8; −3.6) | −6.6 (−8.1; −5.1) | −5.7 (−7.7; −3.7) | −12.7 (−14.5; −10.8)2 | |
| M2 | −9.1 (−11.3; −6.9) | −15.0 (−18.7; −11.3)2 | −5.4 (−7.0; −3.8) | −6.4 (−7.9; −5.0) | −6.4 (−8.4;−4.4) | −13.1 (−14.9;−11.3)2 | |
| M3 | −8.3 (−10.3; −6.3) | −14.8 (−18.1; −11.4)2 | −4.2 (−5.7; −2.8) | −7.7 (−9.1; −6.3)2 | −6.0 (−8.0; −4.1) | −13.8 (−15.4; −12.1)2 | |
| Dietary fiber (g/10 MJ)1 | (n = 2) | (n = 6) | (n = 12) | (n = 14) | (n = 8) | (n = 9) | |
| M1 | −10.8 (−14.5; −7.0) | −10.4 (−12.6; −8.2) | −4.4 (−5.9; −2.8) | −7.3 (−8.8; −5.9)2 | −4.7 (−6.6; −2.9) | −13.5 (−15.3; −11.8)2 | |
| M2 | −9.8 (−13.3; −6.2) | −11.1 (−13.2; −8.9) | −4.1 (−5.7; −2.5) | −7.2 (−8.5; −5.9)2 | −5.7 (−7.5; −3.8) | −13.9 (−15.6; −12.3)2 | |
| M3 | −10.0 (−13.7; −6.3) | −11.0 (−13.2; −8.8) | −4.1 (−5.8; −2.4) | −7.3 (−8.7; −5.9)2 | −5.6 (−7.6; −3.6) | −13.9 (−15.6; −12.2)2 | |
Data are presented as estimated mean weight change from baseline and 95% confidence intervals for each combination of the dietary intake-time-P/B strata interaction after 24 weeks in the linear mixed models, which were adjusted for subject as random effects (M1). In model 2 (M2) additional adjustments for age, gender, baseline BMI, fasting glucose, fasting insulin, and diet allocation as fixed factors were performed. Model 3 (M3) include M2 + additional adjustments of fat E%, protein E%, carbohydrate E%, and fiber g/10MJ as continues variables (except when included as exposure). The displayed n is from M1 at week 24
P/B Prevotella-to-Bacteroides
1The approximate median value among the 49 participants having self-reported dietary intake was used as cut-off and was as following: Fat (31 E%), Protein (20 E%), Carbohydrate (46 E%), Fiber (30 g/10 MJ)
2Significant different (P < 0.05) within P/B-group between lower and higher median of dietary component