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. 2019 Jan 8;6:175. doi: 10.3389/fcell.2018.00175

Table 1.

Details about the studies that used non-PHD HIF-1α stabilizers as hypoxia-mimetic agents.

Sl. No. Study Compound(s) Type of compound Time of administration Stroke model(s) Cell/animal type
1 Liu et al., 2015 miR-335 microRNA Immediately or 24 h after MCAO eMCAO Male Wistar rats
2 Li et al., 2008 Isoflurane Anesthetic 24 h before OGD OGD Hippocampal neurons
3 Li et al., 2012 Isoflurane Not specified (post-OGD/MCAO) OGD/MCAO Male Sprague–Dawley rats; Primary cortical neurons
4 Zhang Z. et al., 2014 NAC Antioxidant 30 min before MCAO MCAO Male Sprague–Dawley rats
5 Badawi and Shi, 2017 MG-132; Epoxomicin Proteasome inhibitor 24 h before MCAO OGD/MCAO C57/BL/6 male mice; Primary cortical neurons
6 Doeppner et al., 2012 BSc2118 Proteasome inhibitor 12 h before MCAO MCAO Male C57BL/6N mice
7 Ratan et al., 2008 Tilorone Antiviral agent 24 h before MCAO MCAO Male Sprague–Dawley rats