Table 2.

Details about the studies that used PHD inhibitors as hypoxia-mimetic agents.

Sl. No.	Study	Compound(s)	Type of compound	Time of administration	Stroke model(s)	Cell/animal type
1	Zaman et al., 1999	DFO	Iron chelator	Immediately or up to 10 h after HCA∗ treatment	Glutathione depletion model	Rat primary neurons
		Mimosine	Iron chelator
		CoCl2	Iron competitor
2	Siddiq et al., 2005	DFO		6 h before MCAO	Glutamate-mediated excitotoxicity/MCAO	Rat primary neurons; Adult male Sprague–Dawley rats
		DHB	2OG analog
		Compound A	Iron chelator
3	Bergeron et al., 2000	DFO		24 h before ligation	Unilateral carotid artery ligation	Male and female Sprague–Dawley rats
		CoCl2
4	Prass et al., 2002	DFO		48 or 72 h before OGD/MCAO	OGD/MCAO	Rat primary neurons; Male Wistar rats
5	Freret et al., 2006	DFO		Before and/or shortly after MCAO	MCAO	Sprague–Dawley rats
6	Baranova et al., 2007	DFO		6 h before or after MCAO	MCAO	Transgenic C57BL6/J male mice
		DHB
		DP	Iron chelator
7	Siddiq et al., 2009	DFO		Before or along with HCA	Glutathione depletion model	HT22 murine hippocampal cells
		DHB
		DMOG	2OG analog
8	Hamrick et al., 2005	DFO		1 h before and during OGD	OGD	Hippocampal cells
9	Mu et al., 2005	DFO		Immediately after MCAO	MCAO	Female Sprague–Dawley rats
10	Hanson et al., 2009	DFO		Multiple times before or after MCAO	MCAO	Male Sprague–Dawley rats
11	Zhao and Rempe, 2011	DFO		Every day up to 4 weeks before MCAO	MCAO	Mice
		DFR	Iron chelator
12	Jones and Bergeron, 2001	CoCl2		24 h before MCAO	MCAO	Male and female Sprague–Dawley rats
13	Demougeot et al., 2004	DP	Iron chelator	15 min before and 1 h after occlusion	Cortical photothrombotic vascular occlusion	Adult male Wistar rats
14	Hoecke et al., 2005	DP		15 min before and 1 h after occlusion	Cortical photothrombotic vascular occlusion	Adult male Wistar rats
15	Ogle et al., 2012	DMOG		24 h before OGD and 2 h after initiation of OGD; 30 or 60 min after reperfusion	OGD/MCAO	Primary neurons; Adult male B6129PF2/J mice
16	Nagel et al., 2011	DMOG		Multiple times before and one time after MCAO	Permanent or transient MCAO	Adult male Wistar rats
17	Reischl et al., 2014	FG-4497	Not specified	6, 24, and 48 h during OGD; 6 h before or soon after MCAO	MCAO	Primary murine astrocytes and HT-22 hippocampal neuronal cells; Male C57BL/6 mice
18	Chen et al., 2014	IOX3	Not specified	One day or immediately before MCAO	MCAO	Male C57/B6 mice
19	Zhou et al., 2017	GSK360A	Not specified	18 and 5 h before MCAO	MCAO	Male Sprague–Dawley rats
20	Kontani et al., 2013	TM6008	Not specified	Immediately after hypoxia	Anaerobic chamber	SHSY-5Y cells
21	Zhang Q. et al., 2014	HLJDT	Unknown	24 h before OGD or MCAO	OGD; MCAO	Rat primary neurons; Male Sprague–Dawley rats

^∗HCA, homocysteic acid.