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. 2019 Jan 8;9:775. doi: 10.3389/fendo.2018.00775

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Copyright © 2019 Ashur-Fabian, Zloto, Fabian, Tsarfaty, Ellis, Steinberg, Hercbergs, Davis and Fabian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C57Bl/6 mice inoculated with 100 B16F10 cells (A) Buphthalmic (enlarged) right eye filled with tumor. (B) Enucleated murine eye showing the intraocular tumor located behind the lens, between the pigment epithelium and retina (H&EX2, arrow). (C) Tumor cells behind the lens labeled for S100(X20). (D) CT scan with lung metastasis (E) Macro metastasis in the lungs. (F) An aggregate of large epithelioid melanoma cells with expanded cytoplasm, large nuclei and prominent nucleoli within it (arrow), is surrounded by typical lung tissue (H&EX40).