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The model of action of RAN in glioblastoma. RAN and its partner KPNB1 regulate nuclear import to promote glioblastoma cell survival and to induce drug resistance in patients (Left). Importazole blocks interactions between RAN and KPNB1, thereby inhibiting nuclear import. The consequences of this blockade are induction of cell death and growth inhibition in glioblastoma (Right).
