Table 2.
The results of 10 proteins in computational prediction and experimental validation.
| Proteins | Computational result | Experimental result | ||||||
|---|---|---|---|---|---|---|---|---|
| Up/down | Means of protein concentrations | Means of relative protein concentrations | P-value | FDR | ||||
| Control | AD | Control | AD | |||||
| GSN | Up | Up | 3512.06 (ng/ml) | 5661.87 (ng/ml) | 56470.35 (ng/g) | 94026.19 (ng/g) | 0.0004 | 0.0013 |
| BDNF | Down | Down | 15.55 (ng/ml) | 12.04 (ng/ml) | 231.09 (ng/g) | 183.97 (ng/g) | 0.0042 | 0.0105 |
| TIMP1 | Up | Up | 1.65 (ng/ml) | 5.18 (ng/ml) | 26.49 (ng/g) | 96.86 (ng/g) | 0.0001 | 0.0005 |
| SERPINF1 | Down | Down | 789.96 (ng/ml) | 515.23 (ng/ml) | 13508.58 (ng/g) | 9117.03 (ng/g) | 0.0345 | 0.0575 |
| ITPRIP | Up | – | 295.20 (pg/ml) | 279.96 (pg/ml) | 3855.06 (pg/g) | 3825.37 (pg/g) | 0.916 | 0.916 |
| TMED10 | Up | – | 75.51 (pg/ml) | 78.10 (pg/ml) | 1145.62 (pg/g) | 1066.62 (pg/g) | 0.1542 | 0.1933 |
| VLDLR | Down | Down | 26.36 (ng/ml) | 11.77 (ng/ml) | 327.92 (ng/g) | 161.63 (ng/g) | 0.0001 | 0.0005 |
| MAPK8 | Down | – | 2.48 (ng/ml) | 2.41 (ng/ml) | 37.33 (ng/g) | 32.98 (ng/g) | 0.1546 | 0.1933 |
| APLP2 | Down | Down | 1.80 (ng/ml) | 1.68 (ng/ml) | 26.62 (ng/g) | 22.83 (ng/g) | 0.0184 | 0.0368 |
| MAPK1 | Down | – | 5.45 (ng/ml) | 5.30 (ng/ml) | 70.31 (ng/g) | 72.60 (ng/g) | 0.7631 | 0.8479 |
In the table, up and down represent up-regulated and down-regulated proteins in the blood samples of AD patients when compared with those of controls.