Table 4.
Factors analyzed in multivariate cox regression with corresponding hazard ratios and p-values.
| Factor analyzed for association with overall survival | Hazard ratio | 95% CI | p |
|---|---|---|---|
| Initial NFS | 0.756 | 0.366–1.561 | 0.450 |
| Initial KPI | 0.246 | 0.112–0.541 | <0.001 |
| Neurologic response to treatment | 0.407 | 0.207–0.798 | 0.009 |
| High-grade myelosuppression after RT | 1.273 | 0.608–2.664 | 0.522 |
| Serum LDH > 500 U/l | 3.592 | 1.611–8.012 | 0.002 |
| Systemic therapy after start of RT | 0.738 | 0.364–1.495 | 0.399 |
Significant p-values indicated in bold type. All variables significant in univariate analysis were included in multivariate modeling. KPI, Karnofsky performance scale index; NFS, Neurologic function scale; RT, radiotherapy; WBRT, whole-brain radiotherapy; CRP, C-reactive protein; LDH, lactate dehydrogenase.