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. 2019 Jan 8;9:1514. doi: 10.3389/fphar.2018.01514

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Copyright © 2019 Xiong, Hu, Chen, Zhang, Zhang, Niu and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The metabolic pathway of FECH and heme. ALA, δ-aminolevulinic acid; ALAD, δ-aminolevulinic acid dehydrase; ALAS, δ-aminolevulinic acid synthase; CPGIII, coproporphyrinogen III; CPGIIIOD, coproporphyrinogen III oxidized decarboxylase; FECH, ferrochelatase; Gly, glycine; Hb, hemoglobin; PBG, porphobilinogen; PBGD, porphobilinogen deaminase; PPIX, protoporphyrinIX PPGIX, protoporphyrinogenIX; PPGIXO, protoporphyrinogenIX oxidase; Suc-CoA, succinyl–coenzyme A; UPGIX, uroporphyrinogen III; UPG?D, uroporphyrinogen III decarboxylase.