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. 2019 Jan 8;9:1428. doi: 10.3389/fphar.2018.01428

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Copyright © 2019 Xu, Xu, Jeong, Qian, Wu, Xia and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of Nrf2 in acute liver injury. The protective effects of Nrf2 in acute liver injury, one is through regulating antioxidant defense-related genes, including sulfiredoxin-1, glutamate-cysteine ligase, and glutathione peroxidase-2, and the other pathway is by promoting its target gene HO-1 and then enhanced autophagy. While its negative regulator-keap1, which by binding to it inhibits Nrf2 activation and Trx1-PI3K/AKT-HIF1-HO-1/CyclinD1 signal pathway and promotes liver injury.