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Role of Nrf2 in HCC. P62 and FGF19 were reported to activate Nrf2 and promote HCC by competing with Keap1 or through FGFR4–GSK3β signal pathway. MiR-340, miR-144, camptothecin, valproic acid, and indazolo[3,2-b]quinazolinones, which were revealed in suppressing Nrf2-dependent pathway and sensitizing HCC cells to anticancer treatments.
