Skip to main content
. 2019 Jan 8;9:3108. doi: 10.3389/fimmu.2018.03108

Figure 5.

Figure 5

Loss of one allele of Jak1 impairs tumor surveillance. (A,B) Jak1fl/+ and Jak1fl/+Ncr1Cre mice were injected s.c. with 106 RMA-Rae1 cells and after 10 days the tumor weight was assessed. Shown are (A) representative tumor pictures and (B) dot plots with horizontal lines representing mean tumor weights ± SEM from 2 independent experiments; n = 6–8 (C,D) Tumor infiltrating NK cells were analyzed by flow cytometry. (C) Representative plots of tumor infiltrating CD3−NKp46+ cells and their percentage among Rae1− cells are shown. (D) Total numbers of tumor infiltrating CD3−NKp46+ cells per gram of tumor and (E) percentages of NKG2D+ NK cells are presented as bar graphs showing mean ± SEM from one experiment n = 4–5. ***p < 0.001.