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. 2019 Jan 8;9:1539. doi: 10.3389/fphar.2018.01539

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Copyright © 2019 Fu, Xi, Wang, Zhai, Wang, Gong, Xu, Yang, Qiu, Wang, Lu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CHB-II-F on tumor cell cycle in the chemotherapy-treated H₂₂ hepatocellular carcinoma mouse model. (A) Saline treated control (Negative control); (B) 5-FU treated control (20 mg/kg); (C) CHB-II-F (16.25 g/kg); (D) CHB-II-F (32.5 g/kg); (E) CHB-II-F (65 g/kg); (F) Yangzheng Xiaoji Capsule treated control (0.78 g/kg); (G) Gap phase 0-Gap phase 1; (H) Synthesis phase; (I) Gap phase 2-Mitotic phase. Data were presented as the mean ± SD from 6 mice. Statistical analysis: ^∗P<0.05, ^∗∗P<0.01 compared with the saline group; ^#P < 0.05 compared with the CHB-II-F (16.25 g/kg) group. No statistically significant differences were found when compared with the 5-FU group or between YZXJC and CHB-II-F groups (P > 0.05).