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. 2019 Jan 8;12:988. doi: 10.3389/fnins.2018.00988

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Copyright © 2019 Ryan, Zarruk, Lößlein and David.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in expression of inflammatory cytokines after pMCAO. The change in the mRNA expression of four key inflammatory cytokines in the brain were assessed by qPCR at 24, 72 h and 14 days after pMCAO in wildtype and CpKO mice. Data are plotted as fold-change on the ipsilateral ischemic side as compared to the uninjured contralateral side. Note the marked increases in IL-1β (A), TNF (B) and IL-6 (C) at 24 h in both genotypes. They remained elevated at lower levels at 72 h. There were no significant changes in expression of IL-10 (D). ^∗p-value ≤ 0.05.