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. 2018 Oct 30;6(1):33–45. doi: 10.1002/acn3.676

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Dimethyl fumarate treatment alters the metabolome of RRMS patients. (A) depicts the change in various tricarboxylic acid cycle metabolites from baseline to the end of the study in both the RRMS and healthy controls groups. (B) includes box plots of eigen‐metabolite values of metabolic modules that differed at baseline between RRMS and healthy control groups. The modules were compared between groups using linear regression and models were adjusted for age and sex. The contents of these modules are listed in Table 2 and Table S1. (C) includes box plots of eigen‐metabolite values of metabolite modules that changed significantly in the RRMS group with DMF treatment. Comparisons were made using generalized estimating equation models. The contents of these modules are listed in Table 3 and Table S2.