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. 2018 Oct 30;6(1):33–45. doi: 10.1002/acn3.676

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Metabolic changes induced by dimethyl fumarate treatment are related to changes in absolute lymphocyte counts and CD8+ T cell subsets. (A) depicts the change in the fatty acid module over the course of the study stratified by development of lymphopenia. The two groups were compared using a paired t‐test. A significant change was noted only in the RRMS patients who developed lymphopenia with DMF treatment. (B) depicts the correlation between the change in absolute lymphocyte counts and the change in fatty acid module eigen‐metabolite values in patients with RRMS over the course of the study. (C) depicts the correlation between the change in the fatty acid metabolite module and the changes in proportion of both the CD8+ effector memory and CD8+ naïve T cells.