Table 2.

MIC for fluconazole (FLC) and clotrimazole (CLTRI) in the presence or absence of acetic acid (AcA, 40, and 60 mM) for several C. glabrata and C. albicans strains.

	pH 4						pH 7
Strain	MIC FLC (mg/mL)	MIC FLC (in the presence of 40 mM AcA) (mg/mL)	MIC FLC (in the presence of 60 mM AcA) (mg/mL)	MIC CLTRI (mg/mL)	MIC CLTRI (in the presence of 40 mM AcA) (mg/mL)	MIC CLTRI (in the presence of 60 mM AcA) (in mg/mL)	MIC FLC (in mg/mL)	MIC FLC (in the presence of 40 mM AcA) (in mg/mL)	MIC FLC (in the presence of 60 mM AcA) (in mg/mL)	MIC CLTRI (in mg/mL)	MIC CLTRI (in the presence of 40 mM AcA) (in mg/mL)	MIC CLTRI (in the presence of 60 mM AcA) (mg/mL)
C. glabrata
C. glabrata CBS138	32	32	16	8	4	2	8	8	8	1	1	0.5
C. glabrata BG2	64	64	16	16	4	2	16	16	32	1	2	2
C. glabrata VG99	64	32	16	8	2	1	16	16	16	1	1	1
C. glabrata VG281	32	32	16	8	2	1	8	16	16	1	1	1
C. glabrata VG216	32	32	16	8	2	1	8	16	16	1	2	2
C. glabrata FFUL887 (FLCR; K274Q GOF CgPDR1 allele)	≥64	≥64	64	≥16	16	2	≥64	≥64	≥64	4	4	4
C. glabrata FFUL674 (FLCR; unknown CgPdr1 GOF CgPDR1 allele)	≥64	≥64	≥64	≥16	≥16	≥16	≥64	≥64	≥64	4	4	4
C. glabrata FFUL677 (FLCR; unknown CgPdr1 GOF allele)	≥64	≥64	≥64	≥16	≥16	≥16	≥64	≥64	≥64	8	8	8
C. glabrata F15 (FLCR; P927L GOF CgPDR1 allele)	≥64	≥64	≤ 0.25	-	-	-	≥64	≥64	≥64	-	-	-
C. albicans
C. albicans SC5314	0.5	≤ 0.25	-	0.1	≤ 0.0125	-	≤ 0.0125	≤ 0.25	-	≤ 0.00625	≤ 0.0125	-
C. albicans CaVG216	0.5	≤ 0.25	-	0.1	≤ 0.0125	-	0.025	≤ 0.25	-	≤ 0.00625	≤ 0.0125	-
C. albicans CaVG485	0.5	≤ 0.25	-	0.1	≤ 0.0125	-	0.025	≤ 0.25	-	≤ 0.00625	≤ 0.0125	-

The MIC was determined by the microdilution method, as recommended by EUCAST.