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. 2019 Jan 8;9:3257. doi: 10.3389/fmicb.2018.03257

Figure 2.

Figure 2

Analysis of troglitazone analogs. (A) Chemical structures of troglitazone analogs. The structures shared in common among troglitazone and its analogs are shown by red and blue. (B) HepG2-hNTCP-C4 cells were inoculated with HBV following treatment with 100 nM preS1 peptide or 25 μM troglitazone analogs as shown in Figure 1B. HBV infection was evaluated by quantifying HBs antigen in the culture supernatant. (C,D) Primary human hepatocytes were treated with or without the indicated compounds (100 nM preS1 peptide and 3, 10, and 30 μM of troglitazone or ciglitazone) and inoculated with HBV as shown in Figure 1B. HBs antigen (C) secreted into the culture supernatant was detected by ELISA. Cell viability was also measured by the MTT assay (D). Data are shown as mean ± SD. Statistical significance was determined using a two-tailed non-paired Student's t-test (*P < 0.05, **P < 0.01).