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. 2019 Jan 8;9:1541. doi: 10.3389/fphar.2018.01541

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Copyright © 2019 Mazella, Borsotto and Heurteaux.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothetical model for the cellular sorting of the complex sortilin/TREK-1. The complex that is probably formed in endoplasmic reticulum (ER) translocates to the Trans-Golgi Network where the PE is cleaved by the protein convertase furin. The complex sortilin/TREK-1 can be addressed via constitutive secretory vesicles from the TGN to the plasma membrane where the PE (PE44) is released in the circulation.