Table 2.
Summary of key genes involved in six calcium-related pathways.
| Calcium-related pathway | Gene symbol | RNAseq gene expression | ||||
|---|---|---|---|---|---|---|
| Fold change (IL-1β/CTRL) | RPKM (CTRL) | RPKM (IL-1β) | FDR | |||
| Mechano- sensitive channel | TRPV4 | + | 1.31 | 159.77 | 209.80 | 0.09 |
| PIEZO1 | + | 4.11 | 107.22 | 440.92 | 0.00 | |
| Ligand-gated ion channel | GRIN2C | + | 2.19 | 0.67 | 1.47 | 0.06 |
| GRIN2D | + | 2.29 | 10.32 | 23.61 | 0.00 | |
| GRINA | + | 2.59 | 21.95 | 56.82 | 0.00 | |
| Voltage-sensitive calcium channels | CACNA1B | — | 15.34 | 2.44 | 0.16 | 0.00 |
| CACNA1E | — | 3.13 | 11.72 | 3.75 | 0.03 | |
| CACNA2D1 | — | 1.72 | 232.39 | 135.42 | 0.00 | |
| CACNA1C | + | 5.20 | 4.13 | 21.44 | 0.00 | |
| Purinergic receptor | P2RX6 | — | 3.69 | 1.88 | 0.51 | 0.00 |
| P2RX4 | — | 1.43 | 20.30 | 14.21 | 0.03 | |
| P2RY2 | — | 1.36 | 12.66 | 9.28 | 0.06 | |
| P2RX5 | + | 1.97 | 4.95 | 9.73 | 0.00 | |
| PLC-IP3 | PLCH1 | — | 14.64 | 3.08 | 0.21 | 0.00 |
| PLCD1 | — | 2.29 | 297.00 | 129.71 | 0.00 | |
| PLCE1 | — | 2.26 | 179.13 | 79.20 | 0.00 | |
| PLCD3 | + | 2.27 | 4.75 | 10.76 | 0.00 | |
| PLCH2 | + | 2.29 | 1.08 | 2.48 | 0.02 | |
| PLCH2 | + | 2.29 | 1.08 | 2.48 | 0.02 | |
| ITPRIP | + | 3.37 | 8.19 | 27.62 | 0.00 | |
| ITPR3 | + | 6.35 | 0.79 | 4.99 | 0.00 | |
| ER store | STIM2 | — | 1.64 | 41.68 | 25.43 | 0.00 |
| STIM1 | + | 1.31 | 14.45 | 18.89 | 0.10 | |
| ORAI2 | + | 1.95 | 2.96 | 5.76 | 0.01 | |
The “−” represents downregulation, and “+” represents upregulation.