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. 2019 Jan 15;5:4. doi: 10.1038/s41421-018-0073-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Zoomed view of the VP1 pocket region in CV-A10 mature virion. The pocket location with respect to the complete CV-A10 protomer is illustrated in a small panel in the lower-right corner. The density corresponding to the pocket factor is highlighted in hot-pink. The entrance of the pocket is indicated by a black arrow. b The hydrophobic pocket (cyan mesh) in VP1 of CV-A10 mature virion is occupied by a natural lipid (hot-pink). c Fitting of putative pocket factor structures from seven known enterovirus structures (CV-A16: 5C4W, CV-B3: 1COV, EV-A71: 3VBF, EV-D68: 4WM8, HRV-16: 1AYN, HRV-2: 1FPN, and PV-1: 1VBD) into the corresponding density in the cryo-EM map of CV-A10 mature virion. d Zoom-in view of the VP1 pocket region in CV-A10 NEP. The same visualization style as in (a) was adapted. No density corresponding to the pocket factor can be observed. e The empty, collapsed pocket (cyan mesh) of CV-A10 NEP. f Comparison of the pocket region between CV-A10 mature virion (blue) and NEP (gray). Here the density and atomic model corresponding to the pocket factor are shown in hot pink