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. 2019 Jan 14;10:190. doi: 10.1038/s41467-018-08122-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Revised model of B cell differentiation in the spleen including the BD_L subset. Currently, it is thought that immature B cells exit the BM and enter the spleen where they undergo sequential differentiation into T1 then T2, which differentiate into either FO B cells or T2-MZP that upon Notch-2 signaling further differentiate into MZ B cells. BD_L are a new mature B cell subset that differentiates directly from the T2 stage. Alternatively, BD_L could be a subset of FO B cells or differentiate from the FO stage