Fig. 6.

The role of cofactors in the meta-metabolome of the O. tauri-D. shibae partnership. Many essential metabolic processes depend on enzyme cofactors derived from B-vitamins, including biosynthesis of some of the cofactors themselves. Red arrows indicate reactions dependent on vitamins synthesised by D. shibae (cobalamin, thiamine), blue arrows indicate reactions dependent on vitamins synthesised by O. tauri: biotin, pABA (leading to folate) and niacin (leading to NAD+/NADP+). Reactions shown are not exhaustive, and in particular there are many more NAD+/NADP+ dependent enzymes