Fig. 7.

147 improves cardiac performance 7 days post AMI. a Experimental design for testing the effects of 147 in the hearts of mice subjected to 30 min of myocardial infarction, and then examined 7 days after the initiation of reperfusion. Red bars depict the bolus administration of the control compound, while blue bars depict the bolus administration of 147. b, f, g Echocardiographic parameters of fractional shortening (b), LV end diastolic volume (LVEDV) (f), and LV end systolic volume (LVESV) (g) (n = 5). Detailed analyses of echocardiography parameters are in Extended Data Table 3. c Ratio of heart weight to body weight (n = 5). d Plasma cTnI (n = 5). e Diastolic function as determined by pulse-wave Doppler (PW) technique to analyze E and A waves (n = 5). h, i qPCR for Grp78 (h) or Cat (i) in LV of mice from indicated experiments at culmination of study (n = 3). Data are represented as mean ± s.e.m. Two-group comparisons were performed using Student’s two-tailed t test, and all multiple group comparisons were performed using a one-way ANOVA with a Newman–Keuls post hoc analysis. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001; ns not signficant