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. 2019 Jan;96:45–55. doi: 10.1016/j.neubiorev.2018.10.026

Fig. 2.

Fig. 2

Maps of statistically significant differences in activation (Voxel threshold = p < 0.005, peak height threshold: peak SDM-Z < 1, clusters ≥ 10). Axial brain slice position shown on a sagittal view bottom right, with slices arranged from left to right in the different panels showing brain slices in ascending order from bottom to top.

A - Activation of current CU compared to non-using control subjects, increased activation in CU shown in red, decreased activation in CU shown in blue (k = 22; CU n = 361, NU n = 394).

B - Activation of adolescent abstinent CU compared to non-using controls, increased activation in CU shown in red (k = 5; CU n = 98, NU n = 106).

C - Activation of adolescent abstinent CU compared to current adult and adolescent CU, increased activation in abstinent users shown in red (CCU: k = 22, n = 361; ACU: k = 5, n = 98).

D - Adolescent current CU compared to non-using controls, increased activation in CU shown in red (k = 4; CU n = 69, NU n = 70).