Fig. 3.

The effects of blocking hypothesized signalling mechanisms of neurovascular coupling in vitro. Summary plot illustrating the percentage means (with 95% confidence intervals) of neurovascular coupling (NVC) responses that remain in conditions of pharmacological or genetic blockade of hypothesized signalling pathways in vitro. Individual data points illustrate the magnitude of the effects of the 36 experimental treatments reported in the publications referenced: K⁺ Channels; (Filosa et al., 2006; Longden et al., 2014, 2017; Longden et al., 2011; Zaritsky et al., 2000), COX; (Filosa et al., 2006; Gordon et al., 2008; Mishra et al., 2016), NOS; (Mapelli et al., 2017; Mishra et al., 2016; Zonta et al., 2003), ATP; (Mishra et al., 2016), AMPA/NMDA; (Hall et al., 2014; Mapelli et al., 2017; Mishra et al., 2016; Zonta et al., 2003), Epoxygenase; (Hall et al., 2014; Mishra et al., 2016).