. 2019 Jan 15;39(1):BSR20181770. doi: 10.1042/BSR20181770

Table 3. Results of meta-analysis for MTR A2756G polymorphism with pediatric ALL risk.

Variables	No.	Sample size		AG vs. AA			GG vs. AA			GG vs. AA+AG			AG+GG vs. AA			G Allele vs. A Allele
		Case	Control	OR (95% CI)	P	P_h^*	OR (95% CI)	P	P_h^*	OR (95% CI)	P	P_h^*	OR (95% CI)	P	P_h^*	OR (95% CI)	P	P_h^*
Overall	10	3224	4077	1.13 (1.02–1.26)	0.02	0.65	1.10 (0.86–1.39)	0.45	0.28	1.05 (0.83–1.34)	0.66	0.33	1.13 (1.02–1.25)	0.01	0.38	1.10 (1.01–1.20)	0.03	0.18
Ethnicity
Caucasian	9	3099	3977	1.14 (1.03–1.27)	0.01	0.58	1.11 (0.87–1.42)	0.39	0.23	1.07 (0.84–1.37)	0.58	0.27	1.14 (1.03–1.26)	0.01	0.33	1.11 (1.02–1.21)	0.02	0.15
Asian	1	125	100	0.99 (0.56–1.73)	0.96		0.78 (0.26–2.36)	0.66		0.79 (0.27–2.33)	0.67		0.95 (0.56–1.62)	0.86		0.93 (0.60–1.44)	0.75
Control source
PB	9	2681	3548	1.15 (1.03–1.28)	0.02	0.58	1.13 (0.87–1.47)	0.37	0.23	1.08 (0.83–1.41)	0.55	0.27	1.15 (1.03–1.28)	0.01	0.33	1.11 (1.02–1.22)	0.02	0.15
HB	1	543	529	1.06 (0.82–1.38)	0.64		0.95 (0.53–1.70)	0.87		0.93 (0.53–1.65)	0.81		1.05 (0.82–1.35)	0.71		1.03 (0.83–1.27)	0.82
Quality
High	7	2824	3024	1.16 (1.04–1.30)	0.008	0.83	1.14 (0.88–1.48)	0.32	0.29	1.09 (0.84–1.41)	0.52	0.31	1.16 (1.04–1.29)	0.006	0.71	1.12 (1.03–1.23)	0.01	0.49
Low	3	400	1053	1.00 (0.77–1.29)	0.97	0.23	0.86 (0.45–1.64)	0.65	0.16	0.87 (0.45–1.66)	0.67	0.20	0.98 (0.77–1.26)	0.89	0.10	0.90 (0.60–1.35)	0.60	0.05

P_h value used to evaluate the heterogeneity between included studies. ALL, acute lymphoblastic leukemia; CI, confidence interval; HB, hospital-based; MTR, methionine synthase; OR, odds ratio; PB, population-based.