Table 2. . Association of tumor infiltrating lymphocytes intensity, distribution and perivascular state with clinical features.

Features	Total n = 39†		p-value	Diffuse, n = 15 (%)	Total n = 39‡		p-value	Total n = 40§		p-value
	Mild, n = 28 (%)	Moderate + marked, n = 11 (%)			Focal, n = 9 (%)	Multifocal, n = 15 (%)		Absent, n = 31 (%)	Mild + definite, n = 9 (%)
Age (years)			0.060				0.097			0.451
Median (range)	53 (98–74)	44 (21–68)		53 (36–73)	37 (13–74)	46 (8–72)		51 (8–74)	47 (37–73)
<48	11 (57.9)	8 (42.1)		4 (21.1)	6 (31.6)	9 (47.4)		14 (70.0)	6 (30.0)
≥ 48	17 (85.0)	3 (15.0)		11 (55.0)	3 (15.0)	6 (30.0)		17 (85.0)	3 (15.0)
Gender			0.798				0.002			1.000
Female	14 (73.7)	5 (26.3)		10 (52.6)	7 (36.8)	2 (10.5)		16 (80.0)	4 (20.0)
Male	14 (70.0)	6 (30.0)		5 (25.0)	2 (10.0)	13 (65.0)		15 (75.0)	5 (25.0)
Karnofsky			1.000				1.000			0.453
≤ 80	10 (71.4)	4 (28.6)		6 (42.9)	3 (21.4)	5 (35.7)		12 (85.7)	2 (14.3)
>80	18 (72.0)	7 (28.0)		9 (36.0)	6 (24.0)	10 (40.0)		19 (73.1)	7 (26.9)
Resection			0.648				0.773			0.457
Subtotal	13 (68.4)	6 (31.6)		8 (42.1)	5 (26.3)	6 (31.6)		16 (84.2)	3 (15.8)
Total	15 (75.0)	5 (25.0)		7 (35.0)	4 (20.0)	9 (45.0)		15 (71.4)	6 (28.6)
Promotor MGMT			0.406				0.775			0.236
1	13 (81.2)	3 (18.8)		7 (43.8)	3 (18.8)	6 (37.5)		13 (81.2)	3 (18.8)
2/3	8 (61.5)	5 (38.5)		6 (46.2)	1 (7.7)	6 (46.2)		8 (57.1)	6 (42.9)
Tumor size (cm)			0.956				0.916			0.133
Median (range)	5 (2–7)	5.1 (3–7)		5 (3.3–7)	4 (2–5.3)	5 (3.2–7)		4.7 (2–7)	5.9 (3.3–6.3)
<5 cm	13 (72.2)	5 (27.8)		6 (33.3)	5 (27.8)	7 (38.9)		17 (89.5)	2 (10.5)
≥ 5 cm	15 (71.4)	6 (28.6)		9 (42.9)	4 (19.0)	8 (38.1)		14 (66.7)	7 (33.3)

^†Four cases do not specify TIL intensity category.

^‡Four cases do not specify TIL distribution category.

^§Three cases do not specify perivascular state.

TIL: Tumor-infiltrating lymphocyte.