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. 2018 Nov 27;6(1):129–143. doi: 10.1002/acn3.687

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The number and frequency of plasmablasts are increased in the peripheral blood of GBS patients treated with IVIg. B‐cell subsets were gated as indicated (A). Total B cells (CD19⁺ cells; (B), naïve B cells (CD19⁺ IgD⁺ CD27⁻; (C), memory B cells (CD19⁺ IgD⁻ CD27⁺; (D), natural effector B cells (CD19⁺ IgD⁺ CD27⁺; (E) and plasmablasts (CD19⁺/low CD27⁺ CD38⁺; (F) were quantified using flow cytometry. The percent plasmablasts of total B cells is shown in G. An increase in the percent of plasmablasts was also found in an IVIg‐treated patient with a spinal cord infarction (H). A representative IVIg‐treated GBS patients is shown in I. *P < 0.05; **P < 0.01; ***P < 0.001.