Structure of human BAK (PDB 2IMS) with the hydrophobic binding groove comprising α‐helices 3–5 highlighted in
blue. The ubiquitination site, K113, (
red) resides in the binding groove. A modelled transmembrane anchor (α9) and the C‐terminal K210 localised to the inter‐membrane space are based on evidence that the BAK transmembrane anchor spans the mitochondrial outer membrane (Iyer
et al,
2015). The orientation of the soluble portion (α‐helices 1–8) of BAK with respect to the mitochondrial outer membrane is hypothetical.