Table 3.

Hazard ratios for patients with prostate cancer compared to patients without prostate cancer

	Patients without prostate cancer (n = 159,662)	Prostate cancer
		Without ADT (n = 13,128)		With ADT (n = 6954)
		Compared to patients without prostate cancer	p value	Compared to patients without prostate cancer	p value	Compared to patients with prostate cancer without ADT	p value
Any fracture (HR (95% CI))
Age, height, weight	Reference	0.94 (0.87–1.01)	0.111	1.46 (1.34–1.59)	< 0.001	1.51 (1.35–1.70)	< 0.001
Traditional risk factors*	Reference	0.96 (0.89–1.04)	0.322	1.42 (1.30–1.54)	< 0.001	1.44 (1.2748–1.61)	< 0.001
Multivariate**	Reference	0.97 (0.90–1.05)	0.449	1.40 (1.28–1.53)	< 0.001	1.34 (1.19–1.50)	< 0.001
MOF (HR (95% CI))
Age, height, weight	Reference	1.02 (0.92–1.12)	0.756	1.55 (1.39–1.73)	< 0.001	1.50 (1.30–1.73)	< 0.001
Traditional risk factors*	Reference	1.03 (0.94–1.14)	0.514	1.51 (1 35–1 69)	< 0.001	1.44 (1.24–1.66)	< 0.001
Multivariate**	Reference	1.01 (0.92–1.12)	0.802	1.44 (1.28–1.61)	< 0.001	1.34 (1.16–1.56)	< 0.001
Hip fracture (HR (95% CI))
Age, height, weight	Reference	0.96 (0.86–1.08)	0.519	1.48 (1 30–1 69)	< 0.001	1.51 (1.28–1.79)	< 0.001
Traditional risk factors*	Reference	0.97 (0.87–1.09)	0.642	1.46 (1.28–1.66)	< 0.001	1.46 (1.24–1.74)	< 0.001
Multivariate**	Reference	0.95 (0.84–1.07)	0.355	1.38 (1.20–1.58)	< 0.001	1.38 (1.16–1.65)	< 0.001
Non-skeletal fall injury (HR (95%CI))
Age, height, weight	Reference	0.96 (0.88–1.05)	0.332	1.20 (1.07–1.34)	0.001	1.21 (1.05–1.40)	0.007
Age, height, weight and Charlson	Reference	0.84 (0.77–0.92)	< 0.001	1.01 (0.90–1.13)	0.920	1.15 (1.00–1.32)	0.057

*Previous fracture, glucocorticoid use, rheumatoid arthritis, estimated over consumption of alcohol, and secondary osteoporosis

**Previous fracture, glucocorticoid use, rheumatoid arthritis, estimated over consumption of alcohol, secondary osteoporosis, Charlson, alendronate, calcium + vitamin D and previous known fall (yes/no)