Table 2.

Incident rates and hazard ratios of subsites of CRC among men and women with T2D and no diabetes

	Men				Women
	T2D	No diabetes	T2DM vs. no diabetes		T2D	No diabetes	T2DM vs. no diabetes
	IR (95% CI)	IR (95% CI)	HRa	(95% CI)	IR (95% CI)	IR (95% CI)	HR*	(95% CI)
Colon and rectum	1.66 (1.43–1.92)	1.31 (1.20–1.43)	1.26	(1.06–1.49)	1.21 (1.00–1.45)	0.95 (0.85–1.05)	1.33	(1.07–1.65)
Proximal	0.47 (0.35–0.61)	0.39 (0.33–0.45)	1.20	(0.87–1.65)	0.55 (0.41–0.72)	0.37 (0.31–0.44)	1.58	(1.13–2.19)
Cecum	0.17 (0.10–0.27)	0.17 (0.13–0.22)	0.96	(0.57–1.62)	0.23 (0.14–0.34)	0.17 (0.13–0.22)	1.37	(0.83–2.27)
Appendix	–	–	–	–	–	–	–	–
Ascending colon	0.21 (0.13–0.31)	0.10 (0.08–0.14)	2.12	(1.26–3.59)	0.18 (0.10–0.28)	0.10 (0.07–0.13)	1.98	(1.09–3.61)
Hepatic flexure	0.05 (0.02–0.12)	0.03 (0.01–0.05)	2.31	(0.83–6.48)	0.08 (0.04–0.16)	0.04 (0.02–0.07)	2.21	(0.92–5.32)
Transverse colon	0.04 (0.01–0.09)	0.08 (0.05–0.11)	0.41	(0.14–1.18)	0.06 (0.02–0.14)	0.05 (0.03–0.08)	1.22	(0.47–3.13)
Distal	0.66 (0.52–0.83)	0.46 (0.40–0.54)	1.42	(1.08–1.88)	0.26 (0.17–0.38)	0.29 (0.24–0.35)	0.86	(0.55–1.35)
Splenic flexure	0.01 (0.00–0.05)	0.02 (0.01–0.04)	0.30	(0.04–2.37)	0.06 (0.02–0.14)	0.03 (0.01–0.05)	2.39	(0.82–6.93)
Descending colon	0.07 (0.03–0.14)	0.03 (0.01–0.05)	2.56	(1.00–6.53)	0.02 (0.00–0.07)	0.03 (0.01–0.05)	0.60	(0.13–2.85)
Sigmoid colon	0.58 (0.44–0.74)	0.41 (0.35–0.48)	1.42	(1.05–1.91)	0.18 (0.10–0.28)	0.23 (0.19–0.29)	0.72	(0.42–1.24)
Rectum	0.46 (0.34–0.60)	0.42 (0.36–0.49)	1.06	(0.77–1.47)	0.33 (0.23–0.47)	0.26 (0.21–0.32)	1.33	(0.88–2.02)

^aAdjusted for age, SES, and the use of aspirin, non-aspirin NSAIDs, statins, antihypertensives, and HRT in the year prior to index date