Table 2.
Soluble ICAM-1 and CEA serum concentrations increase stage dependently in human colorectal carcinoma (n = 297)
| sICAM-1 (ng/ml) | p value | CEA normal (< 5 ng/ml) | CEA elevated (≥ 5 ng/ml) | p value | ||
|---|---|---|---|---|---|---|
| n | Mean ± SD (median) | n (%) | n (%) | |||
| All patients | 297 | 266.5 ± 121.5 (241.4) | 199 | 98 | ||
| UICC stages | ||||||
| Stage I + II | 172 | 251.1 ± 105.2 (233.6) | 136 (68.3) | 36 (37) | ||
| Stage III | 63 | 258.7 ± 80.4 (257.2) | 47 (23.6) | 16 (16) | ||
| Stage IV | 62 | 316.9 ± 175.1 (276.9) | 0.005 | 16 (8.0) | 46 (47) | < 0.001 |
| Male | 185 | 263.5 ± 111.5 (243.8) | 119 (59.8) | 66 (67) | ||
| Female | 112 | 271.4 ± 136.8 (238.2) | 0.897 | 80 (40.2) | 32 (33) | 0.207 |
| Age < 67 years | 146 | 270.1 ± 139.9 (243.5) | 101 (50.8) | 45 (46) | ||
| Age ≥ 67 years | 151 | 263.0 ± 100.9 (239.9) | 0.873 | 98 (49.2) | 53 (54) | 0.433 |
| CEA normal | 199 | 255.5 ± 106.3 (235.9) | ||||
| CEA elevated | 98 | 288.7 ± 145.6 (252.0) | 0.045 | |||
Soluble ICAM-1 soluble intercellular adhesion molecule-1, CEA carcinoembryonic antigen, UICC Union Internationale Contre le Cancer