Table 4.

Univariate and multivariate overall survival analysis

		Univariate analysis			Multivariate analysis
	n	5-year survival (%)	95% CI	p	Hazard ratio (HR)	95% CI	p
sICAM-1low	208	75.2	69.3–81.1		1.0
sICAM-1high	89	52.5	42.1–62.9	0.000023	1.6	1.1–2.4	0.016
CEAnormal	199	82.3	77.0–87.6		1.0
CEAelevated	98	40.5	30.7–50.3	4.123E−10	1.5	1.0–2.2	0.084
Gender
Male	185	63.0	55.9–70.1		1.0
Female	112	77.4	69.6–85.2	0.003	0.6	0.4–0.9	0.008
Age
< 67 years	146	68.9	61.3–76.5
≥ 67 years	151	68.0	60.6–75.4	0.171
Localization
Rectum	66	68.4	56.8–80.0
Colon	231	68.3	62.2–74.4	0.352
UICC stages
Stage I	61	85.0	76.0–94.0		1.0
Stage II	111	80.9	73.6–88.2		0.8	0.4–1.4	0.347
Stage III	63	75.8	65.0–86.6		1.0	0.5–1.8	0.948
Stage IV	62	22.6	12.2–33.0	< 0.001	1.0	0.4–2.5	0.965
R classification
R0	246	80.2	75.1–85.3		1.0
R1	4	25.0	0–67.5		6.6	1.9–23.3	0.003
R2	40	2.5	0–7.4		9.5	3.9–23.1	< 0.001
RX	7	57.1	20.4–93.8	< 0.001	1.9	0.5–7.3	0.356

sICAM-1 soluble intercellular adhesion molecule-1, CEA carcinoembryonic antigen, UICC Union Internationale Contre le Cancer, R classification residual tumor classification