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. 2015 Jul 9;20(7):12545–12557. doi: 10.3390/molecules200712545

Figure 5.

Figure 5

Effects of acerogenin A-induced HO-1 expression through the phosphatidylinositol 3-kinase (PI3K)/AKT cascade. HT22 cells were treated with acerogenin A (30 μM) for the indicated times (A). HT22 cells were pre-incubated with or without 10 μM LY294002 for 1 h and then incubated in the absence or presence of 20 μM of acerogenin A for 60 min (p-AKT) or 12 h (HO-1) (B). HT22 cells untreated or treated with acerogenin A (30 μM) in the presence or absence of LY294002 (10 μM) for 12 h were exposed to 5 mM glutamate for 12 h (C). Western blot analysis was performed, and representative blots of three independent experiments are shown. Data are presented as the mean ± SD values of three independent experiments. * p < 0.05 vs. control. # p < 0.05.