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Cytotoxicity of plumbagin (1) and 11a on HT-29 for 24 h, 48 h, and 72 h.
| Compound | IC50 (μM) a (Mean ± SD) | ||
|---|---|---|---|
| 24 h | 48 h | 72 h | |
| Plumbagin (1) | 4.72 ± 0.07 | 3.67 ± 0.46 | 2.10 ± 0.23 |
| 11a | >20 | 1.99 ± 0.04 | 0.84 ± 0.12 |
a IC50 = compound concentration required to inhibit tumor cell proliferation by 50%. Data are expressed as the mean ± SD from the dose response curves of at least three independent experiments.
