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Derinat significantly inhibited UVB-induced increase of TRPC7 expression in skin cells. The cells were exposed to UVB irradiation after Derinat and 2-APB pretreatment for 30 min. After radiation of UVB for 24 h, expressions of TRPC1, TRPC4, TRPC6 and TRPC7 mRNA, which were detected from total RNA extracts of (A) KCs and (B) HDF, were measured using a qRT–PCR (*, p < 0.05; **, p < 0.01; ***, p < 0.001).
