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. 2015 Sep 2;20(9):16030–16047. doi: 10.3390/molecules200916030

Figure 5.

Figure 5

Competition of the interaction NS5BΔ21:CRE with the selected aptamers. The internally 32P-labeled HCV-CRE194 construct was incubated with a molar excess of the recombinant viral polymerase NS5BΔ21 and increasing concentrations of the aptamers under study, P6-86, P6-96, P6-103, and P7-49. Glycogen was used as a control of the competition reaction. Data were fitted to a non-linear equation to calculate the EC50 value. Values are the mean ± the standard deviation of four independent experiments.