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Anti-RSV activity of the active compounds (n = 3).
| Compounds | IC50/μM a | CC50/μM b | SI c |
|---|---|---|---|
| 4 | 20.0 ± 0.6 | 258.6 ± 7.9 | 12.9 |
| 10 | 6.3 ± 0.2 | >500.0 | >79.3 |
| 12 | 40.0 ± 0.7 | >500.0 | >12.5 |
| Ribavirin | 10.0 ± 1.3 | 255.9 ± 8.2 | 25.6 |
a IC50 was detected by plaque reduction assay after the screening with CPE reduction assay; data are expressed as mean ± SD; b CC50 was tested by MTT assay; data were expressed as mean ± SD; c SI value equals to CC50/IC50.
