Table 1.
SSADH deficiency clinical features (N = 133)
| Pediatric (<12 years) N = 83 (%) | Adolescent/Adult (>12 years) N = 50 (%) | Odds ratio (95% CI) | P value | |
|---|---|---|---|---|
| Intellectual disability | 47 (56) | 29 (58) | 1.058 (0.520–2.151) | 0.877 |
| Fine motor delay | 55 (66) | 38 (76) | 1.612 (0.730–3.561) | 0.238 |
| Gross motor delay | 60 (72) | 38 (76) | 1.214 (0.541–2.722) | 0.638 |
| Speech delay | 63 (76) | 40 (80) | 1.270 (0.539–2.990) | 0.585 |
| Seizures | 31 (37) | 34 (68) | 3.565 (1.697–7.487) | 0.001a |
| Sleep disturbance | 28 (34) | 31 (62) | 3.205 (1.544–6.651) | 0.002a |
| Hypotonia | 65 (78) | 30 (60) | 0.415 (0.192–0.897) | 0.025a |
| Repetitive behavior/OCD | 17 (20) | 29 (58) | 5.361 (2.472–11.629) | <0.001a |
| Ataxia | 46 (55) | 23 (46) | 0.685 (0.339–1.386) | 0.293 |
| ADHD | 43 (52) | 28 (56) | 1.184 (0.585–2.396) | 0.639 |
a
P < 0.05