Table 1.

Baseline characteristics of 180 Chinese with (global ARWMC score ≥2) and without (global ARWMC score <2) severe white matter hyperintensities on MRI brain

	Global ARWMC <2 N = 124	Global ARWMC ≥2 N = 56	P‐value
Age, median (IQR)a, years	69.00 (66.25–73.00)	71.00 (67.00–74.00)	0.083
Education, median (IQR)a, years	7.00 (4.00–12.00)	7.00 (3.25–12.00)	0.932
Male, N (%)b	46 (37.1%)	24 (42.9%)	0.463
MoCA, median (IQR)a	23.00 (21.00–26.00)	22.00 (19.00–25.00)	0.053
Hypertension, N (%)b	62 (50.0%)	44 (78.6%)	<0.001
Diabetes Mellitus, N (%)b	17 (13.7%)	14 (25.0%)	0.063
Hyperlipidemia, N (%)b	30 (24.2%)	17 (30.4%)	0.383
IHD, N (%)c	5 (4.0%)	3 (5.4%)	0.705
Smoker			0.735
Nonsmoker, N (%)c	105 (84.68%)	46 (82.14%)
Past smoker, N (%)c	17 (13.71%)	8 (14.29%)
Current smoker, N (%)c	2 (1.61%)	2 (3.57%)
Alcoholism
Nondrinker, N (%)c	105 (84.68%)	50 (89.29%)	0.477
Occasional (1 drink/week–month), N (%)c	8 (6.45%)	4 (7.14%)
Modest drinker (1–6/week), N (%)c	11 (8.87%)	2 (3.57%)
WMH volume, median (IQR)a, mL	2.53 (1.64–4.34)	10.01 (4.89–18.17)	<0.001
Log‐transformed WMH volume, mean (IQR)a	0.93 (0.50–1.47)	23.00 (1.59–2.90)	<0.001
Presence of Lacunes, median N (IQR)c	2 (1.6%)	8 (14.3)	0.002
Presence of Microbleed, median N (IQR)b	31 (25.0%)	19 (33.9%)	0.281

BMI, body‐mass index; WMH, white matter hyperintensities; ARWMC, age‐related white matter change; IQR, interquartile range.

^aMann–Whitney U test.

^bChi‐square test.

^cFisher exact test.