Table 2.

Independent cross‐sectional predictors for disability, cognition and executive function

		First predictor			Second predictor
	Clinical scores	Covariate	Std. B	P	Covariate	Std. B	P
Cognition	CAMCOG (sqrt)	NfL	−0.593	<0.001*
Cognition	MMSE	NfL	−0.609	<0.001*
Cognition	GIT	NfL	−0.611	<0.001*
Executive function	TMT‐A (log)	Lacunes	0.466	0.008*	NfL	0.382	0.027*
Executive function	TMT‐B	Lacunes	0.401	0.002*	NfL	0.362	0.013*
Disability	mRS	Lacunes	0.455	0.006*	NfL	0.381	0.019*

For clinical scores, the covariate with the best correlation is shown in the ‘first predictor’ column. A second predictor is only shown if it made a significant contribution. Results of forward regression are shown, but were validated with backward regression (not shown). NfL, serum concentration Neurofilament light‐chain; mRS, modified Rankin Scale; CAMCOG, Cambridge Cognitive Examination; MMSE, Mini–mental state examination; GIT, Groningen Intelligence Test; TMT‐A, Trail Making Test part A; TMT‐B, Trail Making Test part B. *P < 0.05.