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. 2015 Oct 23;20(10):19361–19371. doi: 10.3390/molecules201019361

Table 1.

Structures and activity of target compounds 6a–f and 9a–e.

Compounds No. Ar VEGFR2/KDR Inhibitory Rate@10μM (%) IC50(μM) a
A549 Hela MCF-7 PC-3
6a graphic file with name molecules-20-19361-i001.jpg 23.6% ± 12.9% >100 >100 >100 >100
6b graphic file with name molecules-20-19361-i002.jpg 54.0% ± 2.7% 65.86 ± 2.01 >100 72.43 ± 1.96 >100
6c graphic file with name molecules-20-19361-i003.jpg 75.8% ± 5.5% 27.04 ± 1.43 >100 >100 25.35 ± 1.73
6d graphic file with name molecules-20-19361-i004.jpg 61.3% ± 9.6% 86.91 ± 2.03 >100 80.56 ± 2.04 >100
6e graphic file with name molecules-20-19361-i005.jpg 31.4% ± 7.2% >100 >100 >100 68.87 ± 2.14
6f graphic file with name molecules-20-19361-i006.jpg 46.6% ± 1.8% 32.59 ± 1.51 63.92 ± 1.81 16.54 ± 1.22 17.97 ± 1.56
9a graphic file with name molecules-20-19361-i007.jpg <20.0% >100 42.43 ± 1.93 17.19 ± 1.54 ND c
9b graphic file with name molecules-20-19361-i008.jpg <20.0% >100 >100 >100 ND
9c graphic file with name molecules-20-19361-i009.jpg <20.0% 57.42 ± 1.89 >100 >100 ND
9d graphic file with name molecules-20-19361-i010.jpg <20.0% 33.22 ± 1.82 24.65 ± 1.69 >100 ND
9e graphic file with name molecules-20-19361-i011.jpg <20.0% >100 44.32 ± 1.75 69.25 ± 1.96 ND
Sorafenib b - 94.9% ± 1.1% 6.53 ± 0.82 8.08 ± 0.91 4.21 ± 0.62 11.05 ± 1.07
Staurosporine b - 97.3% ± 2.82% ND ND ND ND

a The values are an average of two separate determinations; b Used as a positive controls; c ND: Not determined.