Table 1.
Cyclooxgenanse (COX-1 and COX-2) inhibitory activity.
| Compd. No. | Drug in μg/mL | Percentage Inhibition * | COX-2/COX-1 Selectivity | |
|---|---|---|---|---|
| COX-1 | COX-2 | |||
| 5a | 10 | 3.88 ± 0.0023 | 36.51 ± 0.35 | 9.4 |
| 5b | 10 | 3.84 ± 0.0034 | 59.11 ± 0.44 | 15.4 |
| 5c | 10 | 3.76 ± 0.0023 | 68.34 ± 0.53 | 18.2 |
| 5d | 10 | 3.80 ± 0.0032 | 67.72 ± 0.44 | 17.8 |
| 5e | 10 | 3.92 ± 0.0023 | 75.92 ± 0.36 | 19.4 |
| 5f | 10 | 3.96 ± 0.0034 | 25.31 ± 0.40 | 6.4 |
| 5g | 10 | 3.99 ± 0.0025 | 24.72 ± 0.59 | 6.2 |
| 5h | 10 | 3.62 ± 0.0036 | 20.85 ± 0.38 | 5.6 |
| 5i | 10 | 3.58 ± 0.0025 | 11.50 ± 0.47 | 3.2 |
| 5j | 10 | 3.54 ± 0.0034 | 22.15 ± 0.65 | 6.6 |
| 5k | 10 | 3.51 ± 0.0046 | 12.80 ± 0.74 | 3.6 |
| 5l | 10 | 3.69 ± 0.0027 | 9.58 ± 0.83 | 2.5 |
| Diclofenac | 10 | 56.78 | 7.88 | 0.13 |
| Valdecoxib | 10 | 12.15 | 76.15 | 6.26 |
| Ibuprofen | 10 | 78.89 | 5.23 | 0.06 |
Values were calculated from the mean values of data from three separate experiments and presented as mean ± S.E.M.; * The percentage Inhibition is the percent in inhibition of the either COX enzyme activities at the selected doses; All results are significant different from control values at p ≤ 0.005; All results are significant different from reference standard values at p ≤ 0.005.