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. 2015 Oct 21;20(10):19101–19129. doi: 10.3390/molecules201019101

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of N-acyl-2-methylthio-4-chloro-5-methylbenzenesulfonamides 18–47. Reagents and conditions: (a) K₂CO₃ excess, THF, reflux, 24 h; (b) R¹CH₂Cl/Br, water or methanol, r.t.; (c) PhCH₂Cl, K₂CO₃ excess, THF, reflux, 24 h; (d) R²COOH, reflux (for 45–47 water or toluene).