Table 1.
Staphylococcus aureus susceptibility to methicillin and MLSB antibiotics assessed by the disc diffusion method (Cefoxitin test and D-test) and molecular technique (detection of mecA gene).
| Strain | Cefoxitin Diameter of the Inhibition Zone [mm] | Presence of mecA | Methicillin Resistance Profile | Erythromycin Diameter of the Inhibition Zone [mm] | Clindamycin Diameter of the Inhibition Zone [mm] | Mechanism of Resistance to MLSB Antibiotics |
|---|---|---|---|---|---|---|
| S. aureus ATCC 25923 | 35 | − | MSSA | 25 | 25 | - |
| S. aureus ATCC 43300 | 21 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus ATCC 6538 | 31 | + | MRSA | 30 | 30 | - |
| S. aureus 1 | 34 | − | MSSA | 25 | 25 | - |
| S. aureus 2 | 32 | − | MSSA | 23 | 25 | - |
| S. aureus 3 | 31 | − | MSSA | 0 | 25 | iMLSB |
| S. aureus 4 | 32 | + | MRSA | 25 | 27 | - |
| S. aureus 5 | 13 | + | MRSA | 0 | 30 | iMLSB |
| S. aureus 6 | 31 | − | MSSA | 30 | 35 | - |
| S. aureus 7 | 32 | + | MRSA | 35 | 33 | - |
| S. aureus 8 | 31 | − | MSSA | 30 | 35 | - |
| S. aureus 9 | 30 | + | MRSA | 35 | 25 | - |
| S. aureus 10 | 31 | − | MSSA | 10 | 22 | iMLSB |
| S. aureus 11 | 31 | − | MSSA | 21 | 22 | - |
| S. aureus 12 | 8 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 13 | 14 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 14 | 0 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 15 | 21 | + | MRSA | 25 | 30 | - |
| S. aureus 16 | 18 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 17 | 11 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 18 | 19 | + | MRSA | 25 | 30 | - |
| S. aureus 19 | 14 | + | MRSA | 0 | 0 | kMLSB |
| S. aureus 20 | 19 | + | MRSA | 0 | 0 | kMLSB |
MRSA: methicillin resistance Staphylococcus aureus, MSSA: methicillin susceptible Staphylococcus aureus, kMLSB: constitutive macrolide, lincosamide and streptogramin B mechanism, iMLSB: inducible macrolide, lincosamide and streptogramin B mechanism.