Table 4.
Effects of compounds on NO production in LPS-stimulated RAW264.7 macrophages and cell viability.
| Compound | NO Inhibition Rate (%) | IC50 | Cell Viability (% vs. Control) | |||
|---|---|---|---|---|---|---|
| 3 (µM ) | 10 (µM ) | 30 (µM) | 100 (µM) | 100(µM) | ||
| 1 | 18.0 ± 3.2 ** | 42.9 ± 2.5 ** | 68.9 ± 5.2 ** | 86.6 ± 4.9 ** | 18.0 | 97.3 ± 4.2 |
| 2 | 20.5 ± 2.6 ** | 32.0 ± 4.8 ** | 63.3 ± 5.3 ** | 103.4 ± 5.9 ** | 21.5 | 110.5 ± 0.9 |
| 3 | 18.8 ± 3.0 ** | 29.9 ± 5.0 ** | 59.4 ± 4.7 ** | 98.1 ± 6.5 ** | 23.6 | 106.7 ± 1.5 |
| 4 | 6.3 ± 2.4 | 11.9 ± 5.8 | 15.8 ± 4.4 * | 28.7 ± 5.3 ** | >100 | 101.3 ± 5.0 |
| 5 | 5.7 ± 3.8 | 4.9 ± 7.3 | 16.4 ± 5.4 * | 25.6 ± 4.0 ** | >100 | 91.6 ± 2.3 |
| ibuprofen | ND | ND | 32.3 ± 4.2 ** | ND | ND | ND |
The results were expressed as the mean ± SD. of three independent experiments. * p < 0.05, ** p < 0.01, vs. model group. ND: Not Determined.