Table 1.
Effect of compounds 1–9 on the enzymatic activity of yeast and rat small intestinal α-glucosidases.
| Sample | Yeast | Rat Small Intestinal | ||
|---|---|---|---|---|
| IC50 (mM) a | Maximum Inhibition (%) | IC50 (mM) a | Maximum Inhibition (%) | |
| Acarbose b | 0.50 ± 0.23 | 89.7 | 0.10 ± 0.003 | 80.2 |
| 1 | 1.60 ± 0.07 | 95.2 | ND | 44.5 d |
| 2 b | 0.30 ± 0.02 | 99.6 | ND | 15.2 d |
| 3 b | 0.40 ± 0.02 | 67.8 | 1.98 ± 0.15 | 65.1 |
| 4 b | 0.06 ± 0.005 | 99.0 | 1.63 ± 0.11 | 71.0 |
| 5 | ND c | 45.0 | 3.34 ± 0.38 | 59.7 |
| 6 | 0.03 ± 0.006 | 95.6 | 0.43 ± 0.03 | 75.8 |
| 7 | Inactive | - | 10.68 ± 0.96 | 52.6 |
| 8 | Inactive | - | ND | 39.3 d |
| 9 | 0.03 e | ND | 0.216 e | ND |
a Values present mean ± SD of triplicate experiments; b Positive controls; c Non-determined; d % Inhibition obtained with 10.0 mM of inhibitor; e values taken from reference [22].