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. 2015 Sep 17;20(9):17041–17057. doi: 10.3390/molecules200917041

Table 3.

Scope of carboxylic acids a.

graphic file with name molecules-20-17041-i026.jpg

Entry R Yield (%)
1 Et 3o, 41
2 i-Pr 3p, 35
3 t-Bu b
4 Ph 3q, 26

a Reaction was initiated in the presence of 1d (0.32 mmol), PhI(OCOR)2 (0.40 mmol), RCOOH (0.5 mmol) and BF3·OEt2 (0.8 mmol) in CH2Cl2 (4 mL). Then, 2a (1.5 mmol) was added at −40 °C; b No dioxolane 3 was observed and 2-hydroxy-1-arylethyl pivalate 6 was obtained in 19% yield.